My plan is to get Worth to the top of the Criminal career ASAP so I can do away with that pesky paying for protection deal. Then, when he's done that and able to move someone in, I'm planning on having her reach the top of the Medical career (yeah bathtubs and birth control!) and then I plan for the Gen 2 heir to unlock Science.
It's going to be hard remembering what I can and cannot do, but I think that will make the challenge interesting.
Wish me luck!